I like Orton to shine a bit on offense. I think he will have a fairly good game at best, but I don't think he'll throw a TO, and as a QB on the Bears, that is shining. I think Forte will run for 100 yards, also (given that we aren't down big early).
On defense, I think Harrison is going to make some plays. He is getting the least attention out of all our rookies but I think he'll have a sack, a tipped pass or 2, and I think he'll get some heavy pressure on Manning.